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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c81ea5ca3165b0c4d1d4da09be532127bdea0174ffd6da8e32b71363fa0a52f' 
  AND token = 'h8WXcsnGWOcfdFm1hPZKBt4SfVs+kM8OuF2zQTQXBPc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}