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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2dc9274ba6f4d7c515348b254a0c29d337fcfdaaa781b7fa3f0f47d263670183' 
  AND token = '2U0UhSkIxpxbQPVw+RBW7OFQsQS3oKjB5tJQYJQDD0Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00013

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}