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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2018b1170bba044045bf28e65e119dfcf38acd0db1dac30649eb3a9f9899283a' 
  AND token = 'GTAIfqEC9dWFDzxBBRH8A33t3F2JOvGdr9eyvvBNAF0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00011

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}