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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80065693495297a020661c47759ad4a650a7aa6203291dff35d7017d6402b290' 
  AND token = 'xdOuigLRk+bFrvdM1pcG124zhZgbOZN0DshU/aY1GII=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}