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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78650a569531dbdc0aba57e91eaf53bfc7c641421afcf35b2696cb0487175bd8' 
  AND token = '5BG8RAtmtXWbIqZ+5Q7wZrOjzRlc8uWctE9IS1DQPY0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}