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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1452c42400a4bc430fe4c6d39d6082485ee372a47dc8104c87b9a940909386fa' 
  AND token = 'JgyrEdmbuVvT9ujDoAeYWJWSZY0dLyY+5qDSeZMQbZY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}