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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2dadeabca1e7dba7af8d84e52c7c0f31fc4cabb045bc3b1a02b053d9d874c645' 
  AND token = 'kYZtwa0yyeZUbm5DTooG4VEgu+hwlrZ2wN3gxwiB+5w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}