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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b8d0ba1595f4a82484e112250f1bda70724ea6fa0e74149aff7db65c05f069bb' 
  AND token = 'iyrECvjcx1XVZbM3E4fwSBdNRU3gwXR6ru6ZdtmQdUk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00011

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}