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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1660d157d413f5fdfa39a9a4df808b025c88824be3cc6ff990c01a71024a10d' 
  AND token = 'DKvQNoUEE7jioE2kinpuFdg1bB5nsL168zRPUqsnOmQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}