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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21725a65b169c93c3a7159ee390158ff18f543c7b19a21c7be3f2cf76cb193ed' 
  AND token = 'DNhO3ms8qKJKHI5df/uyWbD13juO6DwpjXNWIwUvBUU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}