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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a7794a29f654f604378d5b39a47eea6948abb0b017bf27d48ea6b8008075ba7f' 
  AND token = 'UdLrp30+SCDk1zalgtN+mQkKHF4ZfSe88bUNhJOSNS0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00010

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}