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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '537f4d369f7812c169138050c7c11b1062add08be4876a3e58586dd1335024b4' 
  AND token = 'haODvAFg5USJYmUCi0c+hs3BMT5CaJVk+YiTrSgUxLc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}