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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '539236899a62e19b147a863fb58bcc3b77c61463ea0281cc233f29650aaf3256' 
  AND token = 'TVCXVSa8Tb4kVvtIFBnkikk0B88i049SFXnUng7+Xtc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}